DNA chips are one of the most important recent break-throughs in
experimental molecular biology. By enabling researchers to make
snapshots of gene expression levels of tens of thousands of genes at a
given moment, DNA chip technology is already producing floods of
valuable data. The analysis and handling of these data is one of the
most important and interesting problems of computational biology.
After briefly discussing how DNA chips work and the challenges they pose
to computer science, we will consider various approaches to analysis of
DNA chip data. We will discuss in more detail the problem of reverse
engineering of gene regulatory networks from gene expression data.
Dr. Brazma works as a leader of Microarray Informatics Team at the European Bioinformatics Institute (EMBL Outstation at Cambridge, UK). He received his Ph.D. in Computer Science from Moscow State University in 1988. His M.Sc. in Mathematics and Physics is from University of Latvia in 1982. Dr. Brazma has worked as Post doc at New Mexico State University in 1991-1992. He has been Associate Professor and Researcher at University of Latvia, Riga since 1994. He worked as visiting researcher at University of Helsinki, Finland in 1995-1997.
Dr. Alvis Brazma
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