Sorry, don't know.
It's possible that your X server got paged out, but the system
doesn't seem to be under any sort of stress, and there's not
much page reclaim happening and no evidence of executable pagein.
I'm assuming that everything is on local disks apart from that
mail file. Really, you haven't told me much. What's all that
`bo' activity there? What filesystems are in use?
Could it be a networking problem? Are your keyboard and mouse
dependent on ethernet traffic in any way (eg: executables on
NFS).
Did the vmstat output exhibit any stalls?
What makes you believe it's a vm/fs thing rather than a keyboard/mouse
thing?
So hm. You'll need to investigate further please.
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