RNA Production Delay Models (Honkela et al., PNAS 2015)

Introduction

This website contains additional material for the paper "Genome-wide modelling of transcription kinetics reveals patterns of RNA production delays" (Honkela et al., PNAS 2015).

The Code

All source code for running the experiments is on a dedicated GitHub repository.

The Model Browser

Plots and key parameters of all the models are available in the Model Browser.

The browser allows sorting and filtering the genes according to various criteria. The second set of plots in the browser shows the pre-mRNA read distribution at different time points.

Reference

A. Honkela, J. Peltonen, H. Topa, I. Charapitsa, F. Matarese, K. Grote, H.G. Stunnenberg, G. Reid, N.D. Lawrence and M. Rattray.
Genome-wide modelling of transcription kinetics reveals patterns of RNA production delays.
To appear in PNAS.
arXiv:1503.01081 [q-bio.GN].